Progress Toward Oral Therapy for Celiac Disease

May 14, 2013

The world’s leading health organizations supporting celiac disease awareness and education (Celiac Disease Foundation, American Celiac Disease Alliance, Celiac Sprue Association, Gluten Intolerance Group and the National Foundation for Celiac Awareness) applaud the efforts of Alvine Pharmaceuticals and AbbVie in addressing the significant unmet medical need for therapeutic treatment of celiac disease.

Origin of celiac disease

How old are predisposing haplotypes?

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Dr. Peter Green [CDF Medical Advisory Board] Co-Authors Study on Mucosal Healing / Fracture Risk in Celiac Disease

Study Title: Mucosal Healing and Risk of Fracture in Celiac Disease (Outcomes: epidemiology)

Presented at Digestive Disease Week - May 19, 2013

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Drs. Joseph Murray and Peter Green [CDF Medical Advisory Board] are Among Esteemed Authors of LPM in Celiac Disease Study

Study Title: Mucosal Healing and Risk of Lymphoproliferative Malignancy in Celiac Disease (Outcomes: epidemiology)

Presented at Digestive Disease Week - May 19, 2013

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CDF Medical Advisory Board Member Alessio Fasano Co-Authors Study on Stem Cell Pathways in Acute Celiac Disease

Study Title: Expression Analysis of Intestinal Stem Cell Signaling Pathways in Acute Celiac Disease (Stem Cells)

Presented at Digestive Disease Week - May 19, 2013

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American College of Gastroenterology Publishes Clinical Guidelines on the Diagnosis and Managment of Celiac Disease.

The list of contributing authors reads like a celiac disease hall-of-fame: Alberto Rubio-Tapia, MD, Ivor D. Hill, MD, Ciarán P. Kelly, MD, Audrey H. Calderwood, MD and Joseph A. Murray, MD.

The guidelines provide 21 pages of much needed information for physicians who tend to perceive CD as a rare disease and often fail to consider it even with typical presentations.

April 2013

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Recognizing Celiac Disease in Kids

Ritu Verma, MD Pediatric gastroenterologist and Director of the Center for Celiac Disease at Children's Hospital in Philadelphia.

Can an Increase in Celiac Disease Be Attributed to an Increase in the 2 Gluten Content of Wheat as a Consequence of Wheat Breeding?

This article was written in response to the suggestion that an increase in the incidence of celiac disease might be attributable to an increase in the gluten content of wheat resulting from wheat breeding.

Gluten-Free, Whether You Need It or Not

Now medical experts largely agree that there is a condition related to gluten other than celiac. In 2011 a panel of celiac experts convened in Oslo and settled on a medical term for this malady: non-celiac gluten sensitivity.

Mucosal Healing and Mortality in Coeliac Disease

A new study from Sweden looks at villous atrophy and mortality in coeliac disease.

Serum parameters in the spectrum of coeliac disease: beyond standard antibody testing - a cohort study

Invasive techniques are still required to distinguish between uncomplicated and complicated forms of CD.

Antibody Repertoire Profiling Using Bacterial Display Identifies Reactivity Signatures of Celiac Disease

A general strategy to identify serum antibody specificities associated with a given disease state and peptide reagents for their detection was developed using bacterial display peptide libraries and multiparameter flow cytometry.

Victory for Celiacs at Lesley University, Cambridge, Massachusetts

In compliance with the Americans with Disabilities Act, which prohibits discrimination against individuals with disabilities by public accommodations, the Justice Department announced an agreement on Thursday, December 20th with Lesley University in Cambridge, Massachusetts.

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College Students With Food Allergies Make Legal Gains from NPR
includes interview with Marilyn G. Geller, Chief Operating Officer of Celiac Disease Foundation

Food (Allergy) Fight: Safe Student Dining a Right from University Business

Prevalence of Migraine in Patients With Celiac Disease and Inflammatory Bowel Disease

Objective: To assess the prevalence of headache in clinic and support group patients with celiac disease and inflammatory bowel disease (IBD) compared with a sample of healthy controls.

Diagnosing Celiac Disease by Video Capsule Endoscopy (VCE) When Esophogastroduodenoscopy (EGD) and Biopsy is Unable to Provide a Diagnosis

Video capsule endoscopy (VCE) is mainly used to evaluate patients with celiac disease in whom their course after diagnosis has been unfavorable and the diagnosis of adenocarcinoma, lymphoma or refractory celiac disease is entertained, but it has been suggested that VCE could replace esophagogastroduodenoscopy (EGD) and biopsy under certain circumstances.

Multicenter Study on Season of Birth and Celiac Disease: Evidence for a New Theoretical Model of Pathogenesis

Objective: To investigate whether season of birth is associated with celiac disease (CD).

Mass Screening for Celiac Disease From the Perspective of Newly Diagnosed Adolescents and Their Parents

Mass screening for celiac disease (CD) as a public health intervention is controversial. Prior to implementation, acceptability to the targeted population should be addressed.

In Vitro Gliadin Challenge: Diagnostic Accuracy and Utility for the Difficult Diagnosis of Celiac Disease

Diagnosis of celiac disease is difficult when treatment with gluten-free diet (GFD) is started before diagnosis and/or when the results of tests are inconsistent. The objective of this study was to evaluate the in vitro gliadin challenge.

Reduced risk of breast, endometrial and ovarian cancer in women with celiac disease

Women with celiac disease (CD) may be at decreased risk of female hormone-related cancers given the observed reduction in breast cancer seen in some cohorts.

Incidence of Lymphoproliferative Disorders in Patients with Celiac Disease

Prior studies describe an increased incidence of lymphoma in celiac disease. However, few studies differentiate among lymphoproliferative disorders (LPDs).

The Incidence and Risk of Celiac Disease in a Healthy US Adult Population

Several factors are hypothesized as possible disease triggers including intercurrent illnesses, such as gastroenteritis, surgeries, and trauma.

Longstanding Celiac Disease a Risk Factor for Diabetic Retinopathy

Longstanding celiac disease is associated with an increased risk of diabetic retinopathy in patients with type 1 diabetes, a new study finds.

Brain Abnormalities Common in Celiac Disease Patients

Patients with celiac disease and neurologic symptoms have substantial structural and functional brain deficits as detected on magnetic resonance imaging (MRI), British investigators have observed.

BioLineRx Announces Pre-clinical Results Demonstrating the Safety of BL-7010

BioLineRx, a biopharmaceutical development company, announced today that BL-7010, an orally available treatment for celiac disease, was found to be safe and well tolerated in pre-clinical studies conducted to date.

ImmusanT Initiates Clinical Trials of Nexvax2 Therapeutic Vaccine for Celiac Disease

ImmusanT announced today that it has initiated clinical trials in New Zealand, Australia and the U.S. to evaluate Nexvax2®, the first therapeutic vaccine for patients with celiac disease.

Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge

Non-celiac wheat sensitivity (WS) is considered a new clinical entity. An increasing percentage of the general population avoids gluten ingestion.

Canadian Celiac Association Celebrates New Gluten Labeling Laws

Three million Canadians with celiac disease and gluten sensitivity will be safer now that new federal legislation on food labeling has gone into effect.

One of every 100 U.S. whites has celiac disease

One percent of non-Hispanic whites in the U.S. - close to two million Americans - have celiac disease, but most are not aware they suffer the gluten-intolerance problem, according to a new study.

Adults with celiac disease needed for a research study!

Alvine Pharmaceuticals is looking for people with celiac disease to test the new survey while eating a food with or without a small amount of gluten.

ALV003 Receives Fast Track Designation From the FDA

Alvine Pharmaceuticals announced today that its lead candidate, ALV003, received Fast Track designation from the U.S. Food and Drug Administration (FDA) for the potential treatment of patients with celiac disease. Alvine is currently conducting phase 2 clinical trials with ALV003.

FDA Safety and Innovation Act

Statement from HHS Secretary Kathleen Sebelius on the signing of the Food and Drug Administration Safety and Innovation Act

The Rewards and Risks of a Gluten-Free Diet

Gluten-free. It's the new buzz word as far as celebrity diets are concerned.

Early Vaccinations Are Not Risk Factors for Celiac Disease

Despite unfounded fears about the side effects of vaccines, the early vaccination of children is not linked to a recent increase in the number of celiac disease diagnoses, says a new study published in the July 2012 issue of the journal Pediatrics.

Gluten-free is not always the way to be

Kim Kardashian and Miley Cyrus are two of the latest celebrities to tout the gluten-free diet as the way to go when it comes to leading a healthy lifestyle, following in the footsteps of the likes of Victoria Beckham, Elisabeth Hasselbeck and Gwyneth Paltrow.

Alba Therapeutics Recruiting for a Phase 2b Clinical Trial

Alba Therapeutics Corporation today announced that it was granted a certificate of registration for copyright of the first and only Patient Reported Outcome (PRO) questionnaire for patients with Celiac Disease (CeD).

FDA Moves Forward on Gluten-free Labeling Rules

Los Angeles, CA – August 2, 2011 – The Food and Drug Administration announced today that it is reopening the public comment period on the gluten-free labeling proposal it issued in 2007, mandated by a seven-year-old allergen labeling law.

University of Maryland School of Medicine Researchers Identify Key Pathogenic Differences Between Celiac Disease and Gluten Sensitivity

Study from University of Maryland Center for Celiac Research Places Gluten Sensitivity on Center Stage of Spectrum of Gluten-Related Disorders

Baltimore, MD – March 10, 2011. Scientists at the University of Maryland School of Medicine’s Center for Celiac Research have proven that gluten sensitivity is different from celiac disease at the molecular level and in the response it elicits from the immune system. The research, published online in BMC Medicine, provides the first scientific evidence of a different mechanism leading to gluten sensitivity. It also demonstrates that gluten sensitivity and celiac disease are part of a spectrum of gluten-related disorders.

Mouse Study Suggests New Clues to Celiac Disease

Retinoic acid might spur digestive disorder in those with genetic susceptibility

By Madonna Behen
HealthDay Reporter

A key discovery into how celiac disease develops may pave the way toward preventing this painful digestive disorder in those most at risk, a new animal study suggests. Using mice, scientists at the University of Chicago have identified a biochemical interaction...

UC San Diego

"Celiac Disease and Gluten: Facts, Fiction & Controversies"
UC San Diego Warren Celiac Center's Community Lecture
With Martin Kagnoff, MD, Kimberly Newton, MD and Shawna McNally, RD